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Is this a significant setback for Bitcoin?
It would also be a significant setback for Isis.
Losing the deal would be a significant setback for EMI.
The announcement follows another significant setback for the field.
Legal experts said the Justice Department's brief was a significant setback for Verizon.
The failed Mariscal Sucre natural gas bid round represents a significant setback for PDVSA.
It's a gift to Big Tobacco and could be a significant setback for public health.
The attack marks a significant setback for efforts to achieve peace in the region.
The Justice Department's announcement represents a significant setback for American's plans to exit bankruptcy.
The emotional fallout from that discovery has been a significant setback for Ms. Smith.
The suspension is also a significant setback for the Dodgers' efforts to increase their Hispanic fan base by marketing Ramirez.
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CEO of Professional Science Editing for Scientists @ prosciediting.com