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The phrase "Significant setback" is correct and usable in written English
It can be used to describe a major obstacle or difficulty that hinders progress in a situation or project. Example: "The team faced a significant setback when the funding was unexpectedly cut."
Exact(60)
"This is a significant setback.
Is this a significant setback for Bitcoin?
This did feel like significant setback.
It would also be a significant setback for Isis.
Losing the deal would be a significant setback for EMI.
The ruling today represents a significant setback to that strategy.
If it's true, it's a significant setback to them".
The announcement follows another significant setback for the field.
But yesterday's acquittal appeared to be a significant setback.
The loss of Smith is a significant setback.
Legal experts said the Justice Department's brief was a significant setback for Verizon.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com