Sentence examples for Significant problematic from inspiring English sources

Treatment of patients within the community may be aborted and transferred to hospital in the event of significant problematic drug-related toxicities, occurrence of a serious adverse event (SAE), on request by the patient, or following discussion between the community chemotherapy nurse and the Investigator who may feel it is in the patient's best interest to do so.

The mismatch is significant and problematic because the Hubble constant is widely regarded as the most fundamental number in cosmology.

As we see in this study, the most significant and problematic feature of our real world automotive stereo data is into camera illumination variance which has to be limited for the dense stereo algorithms to work effectively.

Linking these results to the existing studies of the Lebanese nutritional status and dietary habits, the losses in intakes of zinc, calcium, folate and iron are found to be most significant and problematic particularly because the Lebanese population already has been suffering from highly deficient intakes of these micronutrients.

β-elemene does not produce significant or problematic toxicity and is well tolerated by patients [ 12].

In this regard, some GPs declare factors such as depression or anxiety to be among the most significant and problematic complications in treating patients with chronic pain [ 35].

Nevertheless, drawing inferences from non-significant values is problematic as non-significant results can be indicative of either statistical equivalence or insensitive data.

The results also show a significant difference in problematic internet use in terms of students' programs, though levels of problematic internet use did not differ in terms of sex or ownership of a computer.

Furthermore, academic self-efficacy was determined to be a significant predictor of problematic internet use.

However, two studies did report a significant association with problematic behaviour in school aged children [30, 31], which may affect learning.

These differences in determining a clinically significant outcome are problematic as they make it difficult to compare trials and treatments.