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Significant optimization will be required if this method is to become useful for labeling biomolecules.
Significant optimization determined that both 4 a and 4 b could be accessed by a common route.
Significant optimization of the labeled NASBA protocol was required to maintain the required sensitivity of the reactions.
The latter increases the importance of the non-linear terms in the equation, thus allowing for more significant optimization.
Such efficiency has been achieved on a simple dye-doped device configuration without significant optimization.
With additional AlAs and InAs layers a significant optimization of the structure can be realized.
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Although the framework for incorporating synaptic inputs into computational models is well established, and the computational implications of such inputs have received significant attention, optimization problems involving synaptic inputs are not well represented in the literature.
After significant variables optimization, extraction procedure times were 7 min (7 min per sample) and 70 min (12 min per sample) for enzymatic extraction assisted by pressurisation and microwave energy, respectively.
The adhesive appears to be very performance sensitive to the specific size of the fibre tips, and experiments indicate that designing hierarchical structures is not as simple as placing multiple scales of fibres on top of one another, but can require significant design optimization to enhance the contact mechanics and adhesion strength.
However, while the criterion of overproduction or efficiency is often significant for optimization (or maximization) studies, this criterion is not entirely meaningful in describing cell physiology without a priori objective/selection.
Although this approach potentially resolves many of the analytical issues associated with tryptic digests, Arg-C has been reported to be less efficient and specific than trypsin and requires significant protocol optimization for obtaining reproducible digests.
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CEO of Professional Science Editing for Scientists @ prosciediting.com