Sentence examples for Significant optimisation from inspiring English sources

Significant optimisation of the synthesis was required as high loading resins led to incomplete amino acid coupling when the core amyloidogenic sequence "FYLLYY" was reached.

Before human clinical trials can commence, the mouse model will require significant optimisation, for example increasing the efficiency of new photoreceptors to connect with the damaged retina.

Moreover, the generation of affinity matrices, which immobilise a derivative of the small molecule but also retain the original activity of the molecule, often require significant optimisation.

Significant design optimisation would be required in order to identify efficient, feasible and environmentally sound technical solutions.

As they are not dissociable and their interaction is very significant, the optimisation of a formulation containing a mix of Gelucire cannot be done with polynomial models.

A satisfactory compromise is described here although some features of the method remain open to significant further optimisation.

In addition, even in the case of significant algorithm optimisations, simulating eukaryotic systems that have more than 100 Mbp and 10 TFs becomes impractical.

As the required performance is extremely demanding, significant analysis and optimisation has been required in order to approach a suitable solution.

In fact, efficiency is a very significant factor in optimisation analysis, and the potential for increasing irrigation efficiency is one of the key reasons for deficit irrigation.

Initial results underline the strong influence that the wall material has on plasma performance and regimes of operation but show that there is significant scope for optimisation by careful discharge design.

The current variability and absence of validated approaches and guidelines represent a significant barrier to effective optimisation research.