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The phrase "Significant impact on" is correct and usable in written English
It can be used when discussing the effects or consequences of something on a particular subject or area. Example: "The new policy will have a significant impact on the local economy."
Exact(60)
Significant impact on patient management could be demonstrated.
Both have had a significant impact on our culture.
"We've had a significant impact on the US political system".
And it will have a significant impact on American consumers.
This, of course, has a significant impact on climate change.
Such cuts have a significant impact on career stability.
This could have a significant impact on the city's competitiveness.
"It will have a significant impact on China's economic development".
"It is not having a significant impact on energy investors".
Physician diversity has a significant impact on patients' decisions.
It didn't have a significant impact on our later work.
More suggestions(15)
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com