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It was a significant breakthrough.
That would be a significant breakthrough.
In 2013 he made a significant breakthrough.
It is a very significant breakthrough.
Within two years, he had made a significant breakthrough.
Nonetheless, Zostavax represents a significant breakthrough, several scientists said.
Coomaraswamy believes this week's ICC verdict is a significant breakthrough.
Marconi's most significant breakthrough was yet to come.
Still, the House Republican offer represented a potentially significant breakthrough.
This study provides significant breakthrough in this direction.
I would argue the problem exists throughout all media, making significant breakthrough extremely difficult.
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