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These observations support a novel "serial progression" model of TEC development, in which progenitors serially acquire cTEC lineage markers, prior to their commitment to the mTEC differentiation pathway.
Here, by analyzing whole exome sequencing data of metastatic biopsies from patients, we observed significant genomic overlap between castration resistant adenocarcinoma (CRPC-Adeno) and neuroendocrine histologies (CRPC-NE); analysis of serial progression samples points to a model most consistent with divergent clonal evolution.
The serial progression rate of plaque was compared with change in PAV, measured as follows: (follow-up PAV − baseline PAV /baseline PAV × 100 (23).
BE is a premalignant condition with serial progression from metaplasia to low grade dysplasia (LGD) to high grade dysplasia (HGD) to early cancer to invasive cancer.
In this variant "symmetric serial progression" model (Fig. 1B), one considers that transitional TEPs may begin coexpressing cTEC- in addition to, yet unresolved mTEC-associated genes.
Further studies on the molecular mechanisms regulating the dynamics of the serial progression of the cTEC and mTEC lineages are warranted.
Similar(50)
There are two main hypotheses about mechanisms that drive the sequential progression of actions during serial behavior.
His cruelty ascended, following the classic serial-killer progression, from bullying local kids, causing the death of a harmless animal, to eventually (and controversially) killing a prostitute and spy in his bedroom.
Due to the difficulties inherent in sampling tumor at progression, serial analysis of plasma DNA before and after treatment provides an opportunity to study the genomic evolution of SCLC during and after treatment.
To further investigate IPF disease progression, serial lung function measurements for the first 12 months following baseline were obtained and the percent change in FVC and D LCO were determined.
6 hips with normal scans developed disease after sequential scanning, and overall, 15 hips showed progression on serial imaging.
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