Selective suppression of slow-wave sleep, without a change in total sleep duration, decreased glucose tolerance in healthy subjects (23).
This finding suggested that BRAF acts to suppress CRAF activity and that selective suppression of BRAF catalytic activity activates the MAPK pathway in a CRAF-dependent manner.
This study was designed to characterize a series of pyrazole derivatives in terms of TRPC/Orai selectivity and to delineate consequences of selective suppression of these pathways for mast cell activation.
These observations reveal the D326V mutation selectively abrogates the direct interaction with E2F2/3, but not E2F1, leading to the selective suppression of E2F1 function.
Issuing permits for people to protest and using special event zones as a regular part of convention business concern some who believe such controls border on selective suppression of free speech.
This selective suppression of lower frequencies in the case of glycerol is corroborated by scaling arguments.
Central to the model is the neurobiological mechanism of "selective disinhibition" – the selective suppression of inhibition of the representation of the target stimulus.
Filtered spectra (also referred to as edited spectra) based on specific NMR pulse sequences enabled selective suppression of signals modulated by intrinsic metabolites properties, such as molecular tumbling rate, diffusivity, hydrodynamic radius, and aggregation extent [31, 34].
As a result of this selective suppression, assay sensitivity is increased to such an extent that multiplex PCR assays can be performed in which it is highly unlikely that there will be a false-positive or false-negative result.
These data indicate that selective suppression of the Pmp22 mutant allele by non-viral delivery of siRNA alleviates the demyelinating neuropathic phenotypes of CMT in vivo, implicating allele-specific siRNA treatment as a potent therapeutic strategy for dominantly inherited peripheral neuropathies.
These results show that the selective suppression of cell surface gp96 in gp96tm transgenic mice reduced SLE disease severity.
