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Selective sequestration of these components within SGs occurs in a challenging subcellular environment where aggregate-prone substrates (released by polysomes) tend to accumulate.
The core machinery is modulated with additional Atg components to accommodate the non-selective sequestration of bulk cytosol or the selective sequestration of specific cargoes.
The selective sequestration or compartmentalization of intracellular PKA has been supported by several studies showing that PKA is concentrated in discrete intracellular locales by A-kinase anchoring proteins, or AKAPs [ 1- 4].
Mitophagy is the selective sequestration and degradation of mitochondria using the autophagy machinery (for review, see: Youle and Narendra 2011; Wang and Klionsky 2011; Ding and Yin 2012; Ashrafi and Schwarz 2013; Randow and Youle 2014).
In this study we report about data suggesting the presence of a novel pathway for the degradation of synaptic and secretory vesicles, which involves selective sequestration of vesicle clusters into structures resembling early autophagosomes.
Our findings suggest that selective sequestration of PDI1A in a calcium depletion-mediated complex with the abundant chaperone calreticulin attenuates the effective concentration of this major lumenal thiol oxidant, providing a plausible and simple mechanism for the observed shift in ER lumenal redox poise upon physiological calcium depletion.
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Rather, our findings fit best with non-selective sequestration of both reduced and oxidized PDI1A in lower mobility complex es) in the calcium depleted ER.
OsMT1e-P probably interacts with other physiological processes in the cell for selective uptake and sequestration of ions during salinity stress.
Some studies suggest that soil carbon stocks may decrease after selective logging [47], but carbon sequestration in roots and in the woody debris that are not respired and that return to soil could also be expected [48].
In contrast to the bulk autophagy, which ensures the more or less random sequestration of cytosol, selective autophagy operates under nutrient-rich conditions as well and is characterized by the presence of specialized autophagosomes.
The identification of CpMRP as a non-selective pacemaker involved in the sequestration of plant-derived glucosides highlights how insects counter plant chemical defenses to evolve new functions for the plant-derived toxins as allomones.
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