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There is some evidence to suggest that LTP may offer a selective kill of cancerous cells [ 164, 191– 193], which offers a potential advantage over conventional radiological techniques, where unwanted damage to surrounding tissues is the main concern.
Technically, the apoptotic effect (I) is modelled by a selective kill of a fixed percentage of leukaemic cells per time step (degradation rate rdeg), while the proliferation inhibition (II) is modelled by a reduction of the activation of leukaemic cells into cycle, that is, altering transition characteristic fω to a basal level (Supplementary Figure 1).
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Our in vitro assays confirmed the expression, release and selective killing effect of the immunotoxin produced by hMSCs.
Top216 is a more potent and metabolically stable derivative of Top001, which was discovered by BioImage to have potent and selective killing effect on breast cancer cell lines [28].
Due to its toxic activity, RIPs together with targeting molecules (i.e. monoclonal antibodies) have shown great potential for their use as selective killing agents of tumour, immune or nerve cells in medicine.
At a drug dose of 10 mg porphyrin 7 kg-1 body weight and laser doses of up to 400 J cm-2 light, selective tumour kill with sparing of normal brain was achieved, with a maximal depth of tumour kill of 1.77+/-0.40.
However, nonsurgical approaches are generally not selective and kill both normal and cancer cells, which causes side effects that limit treatment.
In addition, when transcription of HRP gene expression was placed under the control of hypoxia responsive elements (HREs), the combination showed selective cell kill after hypoxic incubation (Greco et al, 2002a).
Designated liver-cancer specific oncolytic virus (LCSOV), it was highly selective in killing HCC cells and in shrinking HCC xenografts.
To enable selective cell-kill, we designed functionalized lipid vesicles with pH-triggered heterogeneous membranes and encapsulated doxorubicin that exhibit tunable surface topography.
This property potentially makes them highly selective for killing targeted single cancer cells, provided that they can be specifically delivered to tumor cells, internalized, and transported to the cell nucleus [3].
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