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Alfy, the human homologue of Drosophila blue cheese, is involved in the selective disposal of ubiquitinated protein aggregates.
Although less well characterized, it is now clear that a basal constitutive macroautophagic activity also exists to contribute to selective disposal of misfolded aggregated proteins or altered organelles.
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A proactive dividend cut and selective disposals should mitigate the need for an expensive refinancing".
Powergen said it would make selective disposals to reduce its debt, which will rise to nearly $5 billion $8 billionon).
A year ago Stora Enso bought Consolidated Papers, another American paper maker, for euro4.9 billion.Other mergers and selective disposals of non-core units have helped big paper firms to reshape their operations.
A latent but powerful substrate-selective disposal process, termed "rapid disposal" (RD), has thus been found in the early post-translational processing of proinsulin.
All in all, CsA was identified as the first selective inhibitor of disposal of a soluble (ERAD-LS), but not of a membrane-tethered (ERAD-LM) version of a misfolded polypeptide with luminal structural defects.
There is substantial evidence supporting the hypothesis that selective resistance to insulin-stimulated (muscle) glucose disposal and the consequential compensatory hyperinsulinemia trigger a variety of metabolic effects, likely resulting in accelerated oxidative stress and aging [ 39, 77].
On the whole, these results point towards IR and β-cell function as phenotypes under strong selective forces during aging, supporting the hypothesis that effective peripheral glucose disposal is pivotal in determining longevity.
In the final steps of RCT, scavenger receptor class B type I (SR-BI), the most physiologically relevant HDL receptor, facilitates the selective uptake of cholesteryl ester (CE) from HDL into hepatocytes for disposal.
Autophagy is not only a nonselective bulk process in response to starvation but also a highly selective quality control mechanism in regulation of organelle turnover, cellular debris disposal, and pathogen clearance.
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CEO of Professional Science Editing for Scientists @ prosciediting.com