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Selected compound 31a was evaluated on SNL model of neuropathic pain and showed inhibitory effect on mechanical allodynia.
Selected compound 28 in combination with tacrolimus prevented allograft rejection in a rat heterotopic cardiac transplantation model.
Selected compound 5 was screened over 442 kinases identifying 5 as a highly potent and selective inhibitor of CK1δ.
Selected compound inhibition data from both studies were mapped to the terminal branches of the respective kinase in the phylogenetic tree.
Selected compound stocks were then purchased separately from Sigma and tested in dose-response assays to confirm that the Spectrum Collection stocks had been assigned the correct identities.
A selected compound (1l; showedAA1) significantinicant in vitro target inhibition and capability to substantially bypass the multidrug resistance mediated by Pgp.
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Selected compounds were tested in in vivo animal models.
Selected compounds were evaluated for neurotoxicity, hepatotoxicity and behavioral study.
Selected compounds were also investigated for their NOD2-inhibitory activity.
Selected compounds were tested in an rat progesterone-sensitive assay.
Selected compounds are structurally related to the template or can be present in biological samples.
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