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Deregulation of TCL1B expression by epimutation could therefore contribute to CHD by secondary disruption of AKT signaling.
It is characterized by fetal anomalies caused by various mechanisms including aberrant embryonic morphogenesis, fetal/embryonal vascular compromise, mechanical deformations and secondary disruption of normally developed structures.
Hence inhibition of HDAC6 may lead to secondary disruption of the autophagy pathway, and further increase susceptibility to infection in the airways of CF patients.
The final collection of 30 secondary disruption containing strains was chosen to comprise a ratio of strains visible at ~14 hrs and ~14 + 24 hours that accounted for the fraction of colonies visible on selection plates at those time points.
WM damage implies primary or secondary disruption of axon function causing disturbance of signal transmission and altered neurological functions that can range from acute, devastating loss of motor function (Hamner et al., 2011) to subtle changes in motor and sensory performance or cognitive impairment (Filley, 2001; Desmond, 2002).
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We hypothesized that this higher than expected rate of lymphedema may be secondary to disruption of arm lymphatics during an SLNB procedure.
They also propose a defense strategy that includes reserving a portion of channels for spectrum handoff in order to reduce the resulting rate of secondary service disruption.
Many of the direct health effects of a burn are secondary to disruption in the normal functioning of the skin.
In animal models, depleting neutrophils reduces ICH-induced brain injury including secondary BBB disruption [ 90, 94].
It is difficult to assess the importance of secondary BBB disruption in ICH.
It is difficult to assess the importance of secondary BBB disruption following ICH that contributed to brain injury [ 33].
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