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"There also seems to be some kind of secondary destruction of the warriors that ended up in the lake, after they were killed".
Understanding which tissue is at risk of secondary destruction following spinal cord injury and the time course over which this damage occurs, is critical for the design and assessment of therapies aimed at limiting consequences of trauma.
As tooth mineral is lost, the proteinase of plaque bacteria causes the secondary destruction of tooth protein.
Its deposition in joints, synovia, cartilage, and bones and subsequent formation of b2m-positive amyloidal fibrils are responsible for the pathogenesis of dialysis-related amyloidosis (DRA) characterized by local inflammation with secondary destruction [ 47, 48].
Sjögren's syndrome (SS) is an autoimmune exocrinopathy characterised by the infiltration of salivary and lacrimal glands by mononuclear cells with secondary destruction of the parenchymal tissue, resulting in oral and ocular dryness [ 1, 2].
These mice also showed the presence of necrotic cells in the intra-articular space, secondary destruction of the joint cartilage, and increased destruction of bone tissue through osteoclastic activation, with sporadic involvement of the bone medulla and extension of inflammatory infiltrate into periarticular soft tissues.
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Over-activation of AMPA and kainate receptors causes oligodendrocyte death and primary and/or secondary myelin destruction (Matute, 2011).
Tracheobronchial dilatation secondary to destruction of the muscular wall of the trachea and the main bronchi, as a tuberculosis sequela.
Paradoxical reactions have recently been recognised to complicate up to 20% of patients receiving antibiotics for BU, [ 5] and can lead to significant secondary tissue destruction [ 6].
At later stages characterized by the presence of macrophages/activated microglia containing myelin degradation products and/or by overt demyelination 3, secondary oligodendrocyte destruction was also observed.
Later it was shown that free radical induced lipid peroxidative damage to the cell membranes is the major factor causing secondary tissue destruction after spinal cord injury [ 7].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com