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Secondary damage, which follows the primary event, can either continue the damaging process in the same cell or expand to other cells (Noell 1980).
Secondary damage occurs following the initial spinal cord trauma.
Secondary damages of cell membranes, edema, and vascular alterations followed by hemorrhage and necrosis are completing the clinical picture.
It looks like secondary damage".
HMGB1-RAGE mediates pro-inflammatory responses that contribute to secondary damage in the acute phase of SCI31.
Targeting of these cytokines represents a potential strategy to reduce the secondary damage in SCI.
The large CMC shuttles show that the CMC expansion can cause extended secondary damage.
A limited number of treatments exist to ameliorate the progressive secondary damage that rapidly follows the primary mechanical impact.
However, dysregulated inflammation can cause secondary damage and could thus contribute to the pathophysiology of many diseases.
However, lateral splash of the round tubes under impact loadings reduces the energy absorption efficiency and may cause secondary damage.
In multi-axial loading experiments, the loading styles were deliberately designed for easier specimen recycling, avoiding secondary damage to samples.
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