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In aged mice [ 28] or those with pre-existing neurodegenerative pathology [ 29], low doses of LPS induced acute and reversible cognitive dysfunction.
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Animals with selective lesions of the basal forebrain cholinergic system have been demonstrated to be susceptible, upon systemic LPS dosing (100 µg/kg), to acute cognitive dysfunction that was reversible upon inflammatory resolution [ 32].
It has been suggested that glial activation not only might be the potential cause of acute, reversible alterations in the mental status, such as delirium, but also may lead to long-term cognitive dysfunction [26].
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