Despite the relatively high stem cell frequency in adipose, the heterogeneity of the uncultured stromal vascular fraction (SVF) restricts its effectiveness as a freshly isolated MSC source.
However, although UA presents the advantage of low toxicity, the clinical application of UA is limited due to several problems, such as its limited water solubility, which leads to a low bioavailability and poor pharmacokinetics in vivo and subsequently restricts its effectiveness [ 13].
Even reports that took the regulator to task for various failings acknowledged that these limitations did restrict its effectiveness.
He noted that cropland expansion and yield increases can have adverse environmental impacts that could restrict their effectiveness.
Without a banking union, cross-border capital flows can be restricted, the effectiveness of monetary policy impaired and, in the extreme, the viability of the union itself undermined.
If Terrell Suggs and Elvis Dumervil can get pressure on the quarterback on Sunday, they might be able to restrict the effectiveness of the Packers' downfield passing game.
Plenty of good teachers favour school choice, knowing it would free them from union rules that restrict their effectiveness.
For the near-CS group, anthropogenic pollution adds ions to the groundwater restricting the effectiveness of the ternary EMMA approach.
However, the complexities inherent in large ER diagrams have restricted the effectiveness of their use in practice.
Note, that the USRP front-end introduces several nonlinearities that restrict the effectiveness of the OOB reduction to approximately -45 dB.
Lord Foulkes said parliament's "preoccupation with 'family friendly' sitting hours has seriously restricted its effectiveness", calling for sittings on weekday evenings and either Monday or Friday to allow "proper time for adequate scrutiny of legislation".
