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Thus, our proposed mechanism for PCNA sliding would ensure that the incoming polymerase encounters PCNA in the correct orientation to efficiently restart synthesis (Fig. 4).
Restart the heart.
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High-resolution structures reveal how it is stopped and efficiently restarted.
It was found that stalled replication forks are efficiently restarted in a RAD51-dependent process that does not trigger HR.
Proper response to DNA damage during S phase requires that stalled replication forks are protected and efficiently restarted (Lambert and Carr 2013; Mirkin and Mirkin 2007).
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