An overview of the response time frame of the above cell lines to 50 µM cisplatin is presented in Table 1.
This includes investigating: a) the identity of the cell populations that respond (stem cells and/or their progeny), as has been done in other adult stem cell systems (Mascre et al., 2012; Simons and Clevers, 2011), b) the level of response (time frame, cell numbers) and c) the anatomy of the response (e.g. the fraction of the niche that becomes activated).
For both prokaryotic and eukaryotic His-Asp phosphorelay signaling pathways, the rates of protein phosphorylation and dephosphorylation determine the stimulus-to-response time frame.
For the remaining three domains (Feelings, Relationships and Daily Life), the response time-frame remained "in the last month".
For Factors 1, 4, 5 and 6 (Treatment Environment and Care, Information and Activities, Education, and Work) this may have been because the response time-frame was "any time since diagnosis".
A quarter of participants (25%, n = 8) commented that they found the response time-frame, "in the past month", did not allow them to express all the concerns about unmet needs they had experienced throughout their cancer journey, especially during treatment.
Features like resolution, response time and frame rate certainly all factor into a TV's overall picture quality, but you'd have to exert a lot of effort to find a set that significantly deviated from its peers in any of those measurements.
During the cognitive interviews, participants were asked to provide verbal open-ended feedback on each item regarding response categories, time frame, item interpretation and overall impression of domain content and coverage.
First, they felt that the new format was easier to use as they were better able to focus on the items and select a valid response for each time frame.
Firstly, since the instrument has been designed a posteriori, the question stems, response options and time frame of the questions were not identical to those from the DEMQOL framework.
Future quality of life expectations were not significantly associated with TTO responses in this study, although they have been shown to influence TTO responses using a time frame linked to full life expectancy [ 10].
