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Accordingly, inconsistent reconstructions induced discordant response classifications amongst the different scenarios, as described in the section below.
In the present study, we evaluated the impact of inconsistent reconstruction on both EORTC and PERCIST response classifications, demonstrating variation in up to 31% of cases for EORTC classification vs up to 18% for PERCIST classification.
We can conclude that, averaged over all subjects, there were no significant differences in the behavioral data, either between stimulus categories or between response classifications.
A 3×3 chi-square test shows no significant differences, either across response classifications or across stimulus categories (df = 4, χ2 = 2.08).
All patient records were subject to central audit for response classification (by E.L., B.Ø. and P.E.L .. Response classifications were completed and approved without any knowledge about result from laboratory analysis.
A 3×3 (stimulus categories x response classifications) repeated measures ANOVA showed no significant main effect either in stimulus category (F2,34 = 0.865) or in response classification (F2,68 = 1.195), and also showed no significant interaction between the two factors (F4,68 = 0.275).
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Response classification uses noise masking to identify the useful information in each single-sensor and multi-sensor image for an observer to make a decision.
Further, we showed that applying the EARL harmonization strategy provided more consistent response classification with kappa values greater than 0.93 for all the scenarios involving harmonized SULs, compared to the OSEMPET1/OSEMPET2 scenario used as a standard of reference.
There is some promise in the recent work by Bittner (2015), which uses response classification (e.g., Ahumada, 2002, Ahumada & Lovell, 1971) to assess the unique information used to make a decision from each sensor image.
These two independent tests results corroborated our immune response classification results (Table 2).
Clinical response was assessed before each treatment cycle, and the final response evaluated 3 weeks after the 4th cycle for overall response classification.
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