This method requires additional modifications prior to standard library preparation.
Upon loss of the pS127, YAP1 is permissive for activation but requires additional modifications for nuclear localization and transcriptional transactivation [ 15, 16, 29, 39], which we find are dependent on loss of the RASSF1A transcript and expression of RASSF1C.
It is known that NF-κB factors (already liberated from the IκB complex) require additional modification through phosphorylation, for example [ 46, 47].
Differences between yeast Rfa2 and human RPA2 might simply be caused by cellular complexity (e.g., human RPA interacts with proteins not found in yeast cells and might require additional modification to regulate these interactions).
This gene therapy is effective in mice, but for application in the clinic, the vector will require additional modification to improve safety and the components for tetracycline gene regulation will need to be engineered to prevent immunogenicity.
Thus, PEGPLA hydrogels are excellent candidates for short-term (< 14 days) acute release of therapeutic factors in the retina, but will require additional modifications for application with neural prostheses.
Extending the model to non-European populations, particularly from Asia and Africa, may therefore require additional modifications and perhaps re-estimation of the model parameters.
This function requires some additional modification to the ODE solver itself, to store calculated values that are used after a certain delay.
The presence of HPV infection alone also is not sufficient to cause tumorigenesis and requires additional cellular modifications such as alterations in the p53 and K-ras genes.
The "UserPatch.groovy" file does not require any additional modification.
Typically, artificial biopolymers require additional surface modification (e.g. with arginine glycine aspartate-containing peptides or arginine glycine aspartate-containingectin), before cell seeding.
