PFGE analysis (data not shown) showed that only 2 isolates (9189 and 12221 from Chile) are clonally related (Appendix Table).
The integrons associated with the sul1 gene vary in size; however, when 2 strains were isolated from the same country (e.g., 3438 and 3444, 9189 and 12221, and 98 and 14469), they possessed integrons of the same size, despite not being clonally related (Appendix Table).
The increment in E by incorporating position and length can be substantial for comparisons involving quite closely related individuals (Appendix Table A1, Table A2, and Table A3).
Newman's assortativity is then given by [ 25] (9) Both measures (8) and (9) are bounded from above by 1, and they can both become negative (indeed, Newman's modularity and assortativity measures are closely related, see Appendix).
For VP7, strains KTM368, Dhaka6, and Matlab36 02 cluster closely within the G11 genotype, together with the G11P[8] strain CUK1 from South Korea; the porcine G11 rotavirus strains YM and A253 are more distantly related (Technical Appendix 2).
Adverse events occurring in ≥5% of lacosamide-treated patients included dizziness, fatigue, nausea, vertigo, headache, and vomiting; except for fatigue, these adverse events appeared to be dose related (supplemental Appendix Table D1).
The European Chemical Agency (ECHA) is in the process of revising nano-related appendices in the existing Technical Guidance to accompany the ongoing revisions to the REACH annexes VIII, IX and X on information requirements [24].
The literature on environmental fate and effects of nanomaterials has expanded vastly, since the latest version of the nano-related appendices to REACH Technical Guidance in 2012 (as summarized/reviewed by Peijnenburg et al. [50], Juganson et al. [59]) and the scientific progress must be incorporated into the upcoming revisions.
Strain diversity at steady-state depends on system parameters and is positively related to resource supply (Appendix Appendix B: Steady-state analysis).
§Diagnostic codes used by the Swedish Board of Health of Welfare since 1987 to report alcohol related mortality (web appendix, table w1).
All trials contributed to the network meta-analysis of pain related outcomes (see appendix 1 on bmj.com).
