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Regulated cell death (RCD) is a critical element in the manifestation of many human diseases, especially tumor formation.
'Regulated cell death' (RCD) can occur as part of physiologic programs or can be activated once adaptive responses to perturbations of the extracellular or intracellular microenvironment fail.
Because of this pioneer finding, regulated necrosis and in particular RIPK1/RIPK3 kinase-mediated necrosis, referred to as necroptosis, has become an intensively studied form of regulated cell death.
Linkermann, A. et al. Regulated cell death in AKI.
However, the identification of programmed necrosis supported the existence of multiple nonapoptotic regulated cell death mechanisms.
Why It Matters: Researchers have long known of one form of regulated cell death called apoptosis.
MTX also induced regulated cell death within C-PVR as assessed by increased expression of caspase-3/7.
However, it is challenging to design experiments that unequivocally prove the advantageous effects of regulated cell death on immunity.
We are using chemical and biological tools to study ferroptosis, a form of regulated cell death discovered in the Stockwell Lab.
In plants, regulated cell death (RCD) plays critical roles during development and is essential for plant-specific responses to abiotic and biotic stresses.
These observations reveal control of MLKL-mediated necroptosis by a metabolite and identify a key molecular mechanism underlying regulated cell death.
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