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Reduced stability of LHCII trimers has been previously reported in the lut2 mutant [ 12].
Reduced stability of ESR1 mRNA was found to be a result of P allele incidence [ 30].
Reduced stability and increased variability appear to underpin circadian rhythm fragmentation and instability in Bdr mice maintained under an LD cycle.
Reduced stability of the U11/U12 complex was confirmed in pulldown experiments (Fig 3B,C) and glycerol gradient analyses (Supplementary Fig 11b) using whole cell extracts.
Recombinant expression of the corresponding protein in Escherichia coli resulted in a protein with reduced enzymatic activity and reduced stability towards denaturants in vitro.
Alternatively, the reduced activity of the monomer may simply be a consequence of its reduced stability or of perturbation of the active site geometry.
The movement faults that a patient presents with – eg reduced glute activation or reduced stability at the pelvis – will form the basis of treatment.
The characteristic cation dependence of G-quadruplex structures was confirmed by the observed reduced stability in the presence of Li+ ions.
De Biasio, A. et al. Reduced stability and increased dynamics in the human proliferating cell nuclear antigen (PCNA) relative to the yeast homolog.
This physical feature may change physicochemical properties, such as causing reduced stability.
Tuning can be extremely difficult due to the reduced stability margins proved for these types of processes.
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