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The significantly reduced efficiencies of the glycolipids 3 & 6 in transfecting primary hepatocytes as well as mice pretreated with asialofetuin (the ligands of asialoglycoprotein receptors) support the notion that the cellular uptake of the lipoplexes prepared from both the open and the cyclic sugar-head series is mediated via asialoglycoprotein receptor.
Larger deletions would likely occur at reduced efficiencies; however, the dsRed marker should still make it practical to find them.
Some of these modified duplexes showed more reduced efficiencies and remaining expression levels of about 25 35%, even for non-azido siRNA species.
Despite the marked loss of the ovarian pool at a young age, Mcl-1cKO females do ovulate and breed, albeit at reduced efficiencies.
The association is dependent on the presence of the lipophilic parts of the GPI anchor [ 15] and painted virus particles remain infectious after insertion of the GPI-linked protein, albeit at reduced efficiencies caused by the duration of the painting process, rather than the actual introduction of GPI-anchored molecules into the viral outer shell [ 7].
Similar(54)
The progressive degradation of batteries leads to reduced capacity, reduced efficiency, and safety concerns.
One result has been reduced efficiency in data centers -- typically measured by the average percentage of computing capacity in actual use.
Healthcare information remains largely siloed and unintegrated, resulting in reduced efficiency, higher costs and poorer outcomes.
This suggests reduced efficiency and capacity of this network in older subjects.
Medication overuse headache (MOH) decreases the quality of life and accounts for reduced efficiency at work.
In our study, VEP changes could in theory also derive from reduced efficiency of inhibitory circuits.
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CEO of Professional Science Editing for Scientists @ prosciediting.com