One effect of NF1 haploinsuffiency used as first read out is the relative mechanosensoric blindness to micro-nano-structures measured as reduced capability to orientate themselves on polydimethysiloxane (PDMS) gels structured with parallel elevations of 200 nm height and a width of 2 µm, as described for fibroblasts derived from NF1 patieNF19.
Description: Old timber sleepers have reduced capability to deal with torque, which might lead to an increased width of the track gauge.
Adverse effects caused by Pb to aquatic organisms such as algae, benthic invertebrates, and embryos and fingerlings of freshwater fish and amphibians include loss of sodium, reduced capability, developmental problems, and distorted algal growth (Freda 1991).
These results may reflect reduced capability of vitamin A depletion mice to maintain homeostasis.
Sperm from men exposed to PCBs and/or PCDFs in adulthood displayed a significantly reduced capability of oocyte penetration (Hsu et al. 2003).
As such organisms are expected to have reduced capability to eliminate deleterious mutations, they are often considered as evolutionary dead ends.
Despite the limited sample size, we found reduced capability in memory and learning in a dose-dependent manner in Yucheng women.
We further aimed to determine whether these straightforward coping preferences were associated with neck pain and reduced capability to work 1 year later.
Abdominal testes of other species apparently have reduced capability to secrete testosterone, although some reports are contradictory (Nef and Parada 1999; Setchell 1978).
A simple nine-item measure of coping preferences is associated with the development of chronic neck pain and reduced capability to work following whiplash trauma and may be used to identify individuals at risk of poor recovery.
Notably, the Y416F mutant of vSrc-dsRed displayed a markedly reduced capability to activate STAT5A, which we attributed to the attenuated kinase activity that has been reported for this construct [ 22].
