A dramatic reduction in point prevalence is seen in association with effective tertiary prevention, because of a lower proportion of subjects in the recurrent episode states in a recurrence at any point in time.
A particular concern is recurrence of infection which occurs in approximately 25% of patients [ 5], with each recurrent episode associated with increased risk of further recurrence and disease severity [ 6].
Two patients had AU for the first time; eight had a recurrent episode of HAU.
In turn, a recurrent episode was defined as the presence, in a previously remitted patient, of symptoms that required either psychotherapeutic or psychopharmacological treatment.
The criteria for defining a recurrent episode of cystitis were rebound lower urinary tract infection symptoms with pyuria and positive bacteriological urine culture.
Control examinations were conducted on day 7 and after 3, 6 and 12 months; or immediately in the case of a recurrent episode.
Patients with at least 3 months of active intraocular inflammation were considered to have chronic uveitis, and other patients to have recurrent episode of acute uveitis, which was normalized between attacks [2].
The International Association for the Study of Pain (IASP) defines trigeminal neuralgia as a sudden, unilateral, severe, brief, stabbing, recurrent episode of pain in the distribution of one or more branches of the trigeminal nerve.
Additional to these standard treatments, the patients in the test group received a Canephron®N therapy for 3 months (2 tablets TID for 3 months), After the initial examination, all patients returned for a control examination on day 7 and for further examinations at 3, 6 and 12 months; or immediately in case of a recurrent episode.
In the 10 years following a VTE, approximately a third of individuals will have a recurrent episode.
This corresponds to a recurrent episode of the disease as compared to patient#1 (Fig. 1A).
