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Recently appreciated among these is their role in the signaling events that lead to the phosphorylation and subsequent desensitization of muscarinic cholinergic (Haga, K., and Haga, T. (1992) J. Biol.
The biological and therapeutic importance of host cellular cofactors for viral replication has been recently appreciated.
Finally, interactions between receptors and the genome are surprisingly rapid, indicating a dynamic aspect of receptor movement only recently appreciated.
More recently appreciated that intra-tumor heterogeneity is of critical importance, each tumor harboring sub-populations that vary in clinically important phenotypes such as drug sensitivity.
Global Crossing's shares had recently appreciated rapidly, and many people on Wall Street scoffed at what they saw as Minow's excessive fastidiousness.
Here, we portray potentially clinically-relevant hallmarks of cancer stem cells and focus on their recently appreciated properties of cell variability and plasticity, both of which make them elusive targets for cancer therapies.
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The following chart is of the Turkish lira vs. the euro; you can see that the lira has been recently appreciating.
While surface chemistry and topography have been studied extensively, substrate mechanics has only recently been appreciated.
For example, the importance of insect pollination to the quality and quantity of agricultural crops such as coffee, almonds and apples, has only recently become appreciated.
But watching Carlson recently, Stevens appreciated Carlson's play near the crease area in front of Holtby, how solid his positioning was when boxing out opposing forwards.
It has been known for decades that alternative sources of antigen, particularly those synthesized within the antigen-presenting cell, can also supply peptides but the impact on TCD4+ responses, sometimes considerable, has only recently become appreciated.
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