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A total of 884 genes were differentially expressed between Reactivated and Not Reactivated DG (FDR < 0.05; Supplementary Data 3).
DEGs between Reactivated and Not Reactivated nuclei (FDR < 0.05) were filtered to maintain only those with expression in at least 80% of Reactivated nuclei, for upregulated genes, or at most 40% of Reactivated nuclei for downregulated genes where the cutoff for expression was placed at 1 log2(TPM+1).
Reactivated infection gives rise to zoster.
Reactivated VZV travels down V/1 and V/2 centripetal distribution.
Reactivated virus was detected by culture of both biopsy (90%) and whole salivary gland specimens (100%) from latently infected mice that received antithymocyte serum.
We sought to determine if a component of the transcriptional signature in Reactivated nuclei was predictive of neuronal reactivity.
Enrollment spiked.
1 rapid enrollment.
These Reactivated neurons from the A > A context represented possible engram cells.
Enrollment plummeted.
Enrollment is about 350.
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