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In normal cells Hsp gene transcription is under the strict regulation of transcription factors belonging to the heat shock factor (HSF) family that ensure prompt switching on of transcriptional activity during stress and equally important post-stress switch off during recovery [1].
In the Development of Antiretroviral Therapy in Africa (DART) trial [ 57] which was done in a clinical trials setting unlike the current study, clinical monitoring alone had a 31% increase in disease progression and mortality compared to clinical monitoring with routine laboratory monitoring implying benefit albeit small associated with prompt switching to second-line therapy.
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Therefore, H1R was suggested to be an effective and prompt "switch" to the regulation of ALDH1 expression and the proportion of CICs in endometrioid adenocarcinoma cell line.
There is indeed some evidence that artificial creation of a DSB adjacent to the 70-bp repeats prompts switching by duplication, and that DSB occur naturally in the repeats in the expression site.
Some authors 70– 72 suggest that the prompt switch to another non-cross resistant agent may reduce the risk of development resistant clones that increases over time.
Anaemia prompted switch from zidovudine to stavudine, while drug induced hepatotoxicity was treated by temporary ATT modification.
[Update: Facebook did not immediately require migration for those whose shrugged off prompts to switch, but plans to push forcibly push Timeline to all users by Fall 2012.].
Doctors were also prompted to switch to regular bronchodilator therapy MDI from day 2 of admission.
If you set up Windows to use local accounts instead of a Microsoft account, you will be prompted to switch to using a Microsoft account.
The changes have prompted a lot of switching between financial companies, and Standard Life is believed to have emerged as one of the winners.
You can switch prompt levels back and forth at any time.
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CEO of Professional Science Editing for Scientists @ prosciediting.com