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Prolonged therapy with SSI as the sole regimen is discouraged.
Prolonged therapy, long-term follow-up and close monitoring are necessary as relapses may occur.
Prolonged therapy with combination antimicrobial agents is suggested in conjunction with complete removal of the device.
Prolonged therapy facilitates colonization with antibiotic-resistant bacteria, which may precede recurrent infectious episodes.
Prolonged therapy with antimicrobial agents apparently is adequate for most patients.
Prolonged therapy beyond 12 months was permitted whether it was determined that a patient would derive benefit from continued therapy.
Prolonged therapy with terbinafine, a drug generally employed for superficial saprophytic infections of skin and nails also was utilized.
Prolonged therapy with oral doxycycline has been associated with success in a large case series of patients with borreliosis-attributed persistent symptoms [ 50].
Prolonged therapy with antibiotics targeting all organisms isolated in a polymicrobial infection and removing infected catheters remain the mainstay in therapy.
Attempting to draw the line between truly preventable problems and those that are the result of prolonged therapy would seem to be a very slippery slope.
Because GERD tends to recur, patients usually need prolonged therapy, and those with severe esophagitis or Barrett's esophagus may need high-dose, lifelong treatment.
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