Sentence examples for Progressive exhaustion from inspiring English sources
This might happen very infrequently at any given time, yet continuously during a life span, leading to the progressive exhaustion of the HSC pool.
Prolonged activation of effector T cells by ICOS ligand could lead to progressive exhaustion.
The voltage is sustained above the transistor threshold for ~ 60 s but subsequently decays due to the progressive exhaustion of the battery electrodes.
Between these two extremes nanofibers with intermediate dislocation densities demonstrated a clear exhaustion hardening behavior, where the progressive exhaustion of dislocations and dislocation sources increases the stress required to drive plasticity.
The reduction of the static toughness in the fatigue damage process indicates the progressive exhaustion of the ability to absorb energy inherent in the material due to fatigue damage evolution, which is associated directly with the irreversible process of energy dissipation of fatigue failure.
The hallmark of chronic viral infections is a progressive exhaustion of antigen-specific CD8 T cells that leads to persisting viral replication.
Like the dilated human heart (Beer et al, 2002), we observed progressive ATP exhaustion in the end-stage HCM male heart (Fig S7H).
Taken together, our data demonstrate the importance of CD40 signaling in the conversion of CTL exhaustion and its ability to enhance PD-1 antagonist action in rescuing exhausted CTLs in chronic infection.
Here, we developed AdVova-infected B6 and transgenic CD11c-DTR (termed AdVova-B6 and AdVova-CD11c-DTR) mice with chronic infection, and assessed a potential effect of CD40 agonist on the conversion of CTL exhaustion and on a potential enhancement of PD-1 antagonist action in rescuing exhausted CTLs in our chronic infection models.
Antibodies targeting NKG2A or Qa-1 prevents NK exhaustion and promotes NK-dependent HCV clearance.
PD-1 blockade using antagonistic anti-PD-L1 antibodies results in a moderate conversion of CTL exhaustion.
