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Fifty-eight of the original cohort (n = 118) had radiographic progression from baseline to mean 8.2-years determined using the van der Heijde modified Sharp method.
For prospective cohort studies, we extracted estimates of the association between baseline knee joint loading and structural disease progression from baseline to follow-up.
For patients who initially received adalimumab and had progression from baseline to week 24, the mean change in mTSS continued to increase from weeks 24 to 144.
Appropriate longitudinal data methods will be used for the assessment of disease progression from baseline disease-free status to disease at follow-up.
A prospective study with detailed assessment of microvascular pathophysiology and NCS progression from baseline would be necessary to answer this question.
Of the 102 patients who had no progression from baseline to week 48, 86 (84.3%) continued to demonstrate no radiographic progression at week 144.
Similar(34)
Subjects altered their foot progression angle from baseline to toe-in gait by an average of 5° (p<0.01), which reduced the first peak of the knee adduction moment by an average of 13% (p<0.01).
The objective of this study was to evaluate toe-in gait (decreased foot progression angle from baseline through internal foot rotation) as a means to reduce the first peak of the knee adduction moment in subjects with medial compartment knee osteoarthritis.
All missing data were imputed using linear extrapolation of the progression observed from baseline to the week 24/week 56 radiographs.
The primary endpoint was inhibition of radiographic progression (change from baseline in modified total Sharp score (mTSS)) at week 26.
These analyses include all individuals with relevant follow-up data for the direct progression rates from baseline to 5 years and high-risk individuals with relevant follow-up data from 1, 3, or 5 years (n = 4,615).
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