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Profoundly disappointing as this would be for patients, without such additional studies, laboratory artifacts cannot be ruled out; also, with the signal exceptions of HIV and human T-lymphotrophic virus, the history of retroviral associations with human disease is not encouraging.
Shale game A new green wave ReprintsThis is profoundly disappointing.
Huang said his treatment by Australian authorities was "profoundly disappointing".
On some days especially it is so profoundly disappointing.
"I had some of my most profoundly disappointing moments in that election," he said.
It is profoundly disappointing if it lacks the courage and vision now to do so.
It's profoundly disappointing, and, for once, I hope that no editor is listening to them.
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Colin Hart, campaign director for the Coalition For Marriage, which opposes same-sex marriage, said: "The decision to press ahead with the profoundly undemocratic proposals to rewrite the traditional meaning of marriage is deeply disappointing and regrettable.
Or, to be fair to Brown and Ban, and tack on the adjectives they threw in, was it not only disappointing, but "profoundly" and "deeply" so?
However, Cary Grant appears to be a profoundly practical man; after the disappointing box-office returns from "None but the Lonely Heart" (he did get an Academy Award nomination for it, but the award was given to Bing Crosby for "Going My Way"), he never tried anything except Cary Grant roles.
The opening-night program on Tuesday featured three profoundly affecting repertory works, one sterling guest artist and one disappointing premiere.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com