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Soon, however, many became upset by the Taliban's purist onslaught on tribal customs, and resented being forced into the army and commanded to cease growing opium poppies at a time of profound economic desperation.
That is not in any way to dismiss the profound sense of meaninglessness and desperation that consumes the one who suffers.
The reasons for migration are diverse: for some, it is necessitated by civil conflict, natural disaster, development, or trafficking; while for others, it is out of desperation to escape profound poverty.
Profound Lore.
Profound things.
But her recent "silliness" is not borne from malice (desperation? partly) but from her profound belief that she really is better prepared and more capable than Senator Obama at being the next president.
Something about the pelican's shadow, darkening her heart and mind with the absurd desperation, must be connected with some profound and secret dread, but she could not seem to put her finger on it.
This, not desperation, is why there are so many profound spiritual experiences near death.
She noticed that the sense of loss and desperation experienced by homeless gay Mormons appeared more profound than that experienced by kids from other faiths.
In desperation, each turns to John Singer Henry Stramm), a gentle-eyed mute, taking his passive friendliness for profound understanding.
Mao's vision of borrowing water from the Yangtze for the north had an almost profound simplicity, but engineers and scientists spent decades debating the project before the government approved it, partly out of desperation, in 2002.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com