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As Dr. Maureen A. Gang, an attending doctor in the Bellevue emergency department, put it, "Grandma might have profound dementia.
If it does, a severe injury would be expected – devastating encephalitis, or profound dementia with an inability to form new memories (from damage of the medial temporal lobe, the part closer to midline) as well as retain old ones.
I have seen malignant forms of Alzheimer's that lead to profound dementia and death in a year, while other patients may have years of good life and decline only very slowly; I have seen patients in whom intellectual loss and personality change are prominent from the start, and others in whom such changes may not occur until the very last stages of the illness.
The drive to diagnose Alzheimer's before it has progressed into profound dementia is also reflected in a bill introduced in Congress this month, which would create specific Medicare cost codes for Alzheimer's diagnosis, including steps involving discussions between the patient's doctor and caregivers, a recognition that keeping family members well-informed can result in better planning and care.
Patients were excluded if they had delirium at admission, metastatic hip cancer, history of bupivacaine allergy, use of cholinesterase inhibitors, severe coagulopathy, Parkinsonism, epilepsy, levodopa treatment, delay of surgery of more than 72 h after admission, and inability to participate in interviews (profound dementia, respiratory isolation, intubation, aphasia, coma or terminal illness).
He was sure the record would speak for itself, and now he can't even speak for the record, as he is hospitalized with profound dementia.
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Autopsies of athletes — notably the brains of former N.F.L. players who suffered from profound dementias — consistently found dark clusters of nerve cell proteins, formations more common to elderly Alzheimer's patients.
They will suffer profound muscle weakness, dementia, learning disability, heart disease and early death.
Specifically, dance and movement improvisation uses frontal lobe resources while movement relies on path integration and visual tracking, which activate the hippocampal and entorhinal networks associated with spatial memory—an area of profound impairment in dementia [ 17].
The onset of Alzheimer's dementia has profound implications for health, social and economic well-being of all the people in whom this disease develops.
On the basis of data from biomarkers, AD can be reconceptualized as a progressive disorder that advances from biological changes in the brain with no accompanying cognitive abnormalities, to a state of memory impairment with biomarker abnormalities indicative of AD, to mild, moderate, severe, and profound stages of AD dementia.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com