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One is that the problem is profound and long term: we are consuming our planet.
Inhibition of negative feed-back loops leading to profound and long term activation of signals often lead to a dysregulation of neovascularisation since the overshooting response is inducing immature vessels.
They were unable to access the detailed personal information they felt they needed to monitor their health and this contributed to profound and long term disruption in their lives.
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It seems almost too pat to suggest that Terry's pursuit of extreme sports stemmed from a profound and long-term unhappiness, but it is hard to avoid the conclusion.
My disability is invisible; you wouldn't be able to tell from looking at me that I have a condition which has a profound and long-term impact on my life.
Mike Reilly, the chief executive of Goalball UK, said the decision would have a "profound and long-term detrimental impact" on his sport.
Inquiry chair, Prof Karen Yeung, said: "The implications for society are extensive, profound and long-term". The use of genome editing in embryos for assisted reproduction in humans is currently prohibited by UK law, but is permitted in some research.
It said in a statement: "This would have a profound and long-term positive economic impact on the area selected for the site, stimulating local businesses, supply-chains, and providing skilled jobs and training opportunities.
This decision was taken because additional controlled data on the safety of profound and long-term acid inhibition on the morphology of the gastric mucosa seemed warranted, well aware of the current recommendations.
The integrity of the trabeculodescemetic window allows controlled outflow of aqueous humor, which reduces the risk of profound and long-term hypotony, and it also has been postulated to prevent egress of cytokines and inflammatory mediators from the anterior chamber into the subconjunctival space, which reduces the risk of inflammation, scarring, and failure of filtering surgery [ 39– 41].
They had published papers from April 2000 onwards that showed that ketamine had a profound impact on short and long term memory.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com