Sentence examples for Profound alteration from inspiring English sources

This rate of change signifies a profound alteration of global climate, and in turn will radically alter agriculture, human occupation patterns and the distribution of the Earth's natural ecosystems.

But it's also about a profound alteration that these scientists wrought in the way we look at reality.

Paget Disease of the bone is a metabolic disorder which leads to a profound alteration of the bone's architecture.

But only one book had such a decisive impact that I can date to it a profound alteration in my worldview and even behaviour.

This state of development required a profound alteration in the genetic template to produce short pelvic blades, a forward-pointing big toe (adducted hallux), and other bipedal traits.

Overall, cannabis may provoke a profound alteration in brain neurotransmission and, in particular, in the mesolimbic system, where it can rearrange the molecular architecture at the synaptic level.

His findings do not require any profound alteration in the way the French are viewed, namely as a people whose behavior in sum was deeply flawed and who are resistant to admitting those flaws.

These biochemical and metabolic changes alter inward and outward transmembrane ionic current fluxes, causing profound alterations of the resting membrane and action of potential characteristics of the myocyte.

"Their genetics haven't changed, but their lifestyles have undergone profound alterations," the authors said.

Profound alterations in nerve trunks, neurons, and the central nervous system are induced rapidly after injury.

Senescence of neural systems is associated with profound alterations in connective anatomy and tissue architecture.