According to Mark Pelling (2011: 74) transitions or incremental changes can be seen when 'the aims and practices of geographically or sectorally-bound activities push but do not overturn established political regimes', while transformation 'is an extreme case where profound change alters the distribution of rights and responsibilities and visions of development across society'.
Like Chigurh, he had the profound ability to alter the fate of lives by the simplest of means.
These biochemical and metabolic changes alter inward and outward transmembrane ionic current fluxes, causing profound alterations of the resting membrane and action of potential characteristics of the myocyte.
Despite the positive benefits of capacity management, it will take other changes of a more profound nature to significantly alter the cost and time it takes to bring a new drug to patients in need.
Disability advocates have been stonewalled for years trying to get this profound work disincentive altered.
Characteristic features included severe alopecia (30% of mice); enlarged lymph nodes and spleen; and profound immunological abnormalities (altered cytokine levels, hypoimmunoglobulinemia) leading to reduced immune responsiveness.
Australian Catholic Bishops Conference public policy director, Jeremy Stuparich, said allowing same-sex marriage would lead to "profound social change" that would "alter the character of the community".
They have been among the worst-performing stocks this year as the industry undergoes a profound shift that promises to alter permanently the way many of these companies do business.
For all the discussion Facebook has prompted — over its "25 random things about me" narcissism, its mangled syntax ("Peggy is weekend"), the tricky politics of whom to friend (actual friends? strangers? "kinda knows"?) — its most profound impact may be to alter, even obliterate, conventional notions of the past, to change the way young people become adults.
I loved the rueful, melancholy comedy of Adrian Mole as soon as I encountered him: his nerdy aestheticism was a profound influence on my teenage alter ego in The Rotters' Club, Benjamin Trotter, whose unrequited passion for Cicely Boyd mirrors Adrian's equally hopeless infatuation with Pandora.
It's the onslaught of profound life-altering realizations that you maybe should write down somewhere and remember for the future.
