As *CDM is produced by human cells in a chemically defined culture medium and is mechanically robust, it may be a viable living tissue equivalent for many connective tissue replacement applications requiring initial mechanical stability yet a high degree of biocompatibility.
In this report we demonstrate that C. albicans biosynthesizes resolvins that are chemically identical to those produced by human cells.
Since the activity is produced by human cells and manifests in mouse cells, it is likely that the secreted proteins are evolutionarily conserved.
The high resistance of Staphylococcus aureus to CAMPs produced by human cells may contribute to epithelial colonization and resistance to destruction by neutrophils.
Our study demonstrates a direct role of the IGF-II/IGF1R axis on human ES cell physiology and establishes that hdFs produced by human ES cells themselves define the stem cell niche of pluripotent human stem cells.
We have previously reported that immunosuppressive cytokines, including IL-6, IL-10, and VEGF produced by human melanoma cell lines with activated mitogen-activated protein kinase signalling via BRAF mutation, cause impairment of human Mo-DCs (Sumimoto et al, 2006).
Indeed, even if bevacizumab is able to bind and inhibit human VEGFA but unable to neutralize murine VEGFA, VEGFA in these 2 xenografts is produced by human cancer cells rather than by mouse stroma cells.
Angiogenic factors include pleiotrophin and vascular endothelial cell growth factor (VEGF), which have been shown to be produced by human IVD cells, with increased expression seen in discs with higher numbers of blood vessels [ 33, 34].
Consistent with these prior works, we found that the Aβ produced by human neuron cells has the capacity to stimulate the expression of COX-2 in glial cells (Fig. 5).
Taken together, these data demonstrated that K12 is produced by human TE cells and thymic fibroblasts, and is regulated in thymus by IFN-gamma.
