Sentence examples for Principal endpoint from inspiring English sources
OS has been the principal endpoint influencing regulatory decisions regarding targeted therapies for metastatic NSCLC, including the vascular endothelial growth factor monoclonal antibody bevacizumab in the frontline setting and the epidermal growth factor receptor tyrosine kinase inhibitors gefitinib and erlotinib in patients after prior treatment.
Finally, it is likely that the two studies were underpowered to demonstrate a difference in the principal endpoint.
The principal endpoint of the study was the clinical response at week 24, according to the clinical criteria DAS28.
Controlled cell destruction with minimum side effects and energy expenditure is the principal endpoint in tissue and tumor ablation, sterilization, and food processing, whereas in other applications such as gene electrotransfer, the cell death is a major outcome to avoid.
Despite these obvious limitations in power, survival experiments with this design were approved and executed because pilot tests strongly suggested that using dissemination as their principal endpoint could generate enough power to demonstrate significant differences between both products.
The principal endpoint for the study is the development of pneumonia.
The principal endpoints of the study were the LOS and the 1 year mortality after an SCIC admission.
Principal endpoints included glycemic control, the occurrence of hypoglycemia, and control of vascular disease risk factors.
These comparisons have in general been made two-by-two with as principal endpoints the duration of the procedure, failure rate defined by a switch to an alternative technique, the rate of major complications, and the rate of minor complications.
Our sample size of 200 ensures adequate power for the two principal endpoints of change in pain and change in knee cartilage volume.
Annual pubertal stage assessments were performed by physicians or nurse practitioners according to BCERP consortium-standardized protocols; the principal endpoints were age at first pubic hair and breast development as described in detail previously [ 27].
