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Clinical accuracy was assessed by calculating the proportion of patients in which the predicted dose was 1) within 20%% of the actual dose (ideal dose prediction); 2) at least 20%% below the actual dose (underprediction); or 3) at least 20%% above the actual dose (overprediction) [ 6].
The capability of candidates to predict dose was compared using mean absolute error (MAE) of predicted dose vs. actual dose.
Lesion volumes were propagated on to the co-registered MAA predicted dose map and 90Y treatment dose map.
The margin of exposure (or MOE) of a NM is the ratio of its no-observed-adverse-effect level (NOAEL) to its predicted dose.
The observed data in this figure are dose modification results from in vitro experiments, while the predicted dose increase is based on the gold concentrations and X-ray energies used.
Whilst a doubling in dose to the maximum predicted dose calculated for hu3S193 wild type was predicted and a doubling in the tumour-to-blood AUC ratios achieved, the dose needed for tumour eradication in patients is likely to be higher than that achievable with a single infusion.
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Accuracy was assessed by calculating the difference between predicted and actual dose, with results expressed as the percentage prediction error [(predicted dose-observed dose)/observed dose*100].
The predicted dosing window is highly accordant with the final dose recommendation based upon extensive clinical studies.
The predicted dose-dependent changes of Cmax and AUC were consistent with the observed data.
The predicted dose-response curves for all five PAHs indicated a good estimation.
Further, we found no departure from the predicted dose-additive curve regardless of the mixture dosing protocol used.
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