Sentence examples similar to Potentially unfolded from inspiring English sources
Here we discuss about the potential relevance of the definition of HIPK2 as a target for AD and highlight the existence of a novel amyloid-based pathogenetic mechanism in AD involving HIPK2 and unfolded p53, potentially leading to the survival of injured dysfunctional cells.
Potentially this sequestration of damaged proteins serves to prevent unnecessary induction of the unfolded protein response, which will lead to protein synthesis inhibition [2], [6].
Potentially, this large increase in protein levels could upset protein folding homeostasis, e.g., by increasing levels of unfolded proteins in the endoplasmic reticulum (ER).
Accumulation of misfolded or unfolded proteins that are potentially toxic poses a threat to cellular integrity.
One such protective but potentially deleterious cellular mechanism is the unfolded protein response (Wang and Kaufman, 2012).
Recent studies have shown that signaling molecules involved in the unfolded protein response (UPR) are potentially involved in the coupling of bone resorption and bone formation [ 1- 3].
Increased accumulation of unfolded proteins, and thus UPRmt can potentially compromise mitochondria function causing increased ROS accumulation and degradation of mitochondria.
The occasionally punctate pattern of LC3 staining under basal conditions may indicate that the lentiviral overexpression system may induce more basal autophagy, potentially as a consequence of ER stress and an unfolded protein response [42]; [42].
