Furthermore, patterns in S-helix domain architectures strongly indicate a certain positional polarity in the function of the S-helix, potentially indicating a role in transmitting signals from one domain to another.
5 In addition, food deprivation causes a reversible decrease in BDNF protein in the DVC, potentially indicating a role for DVC BDNF signaling in mediating metabolic feedback.
Augmented NR2F1 expression has been identified in the pre-disease state of multiple sclerosis patients, potentially indicating a role in the development of autoimmune disease [ 49].
Furthermore, other inhibitors indicated to inhibit PKC also reduced acid secretion and bone resorption, potentially indicating a role of PKC in osteoclast-mediated acidification, although the specificity of all inhibitors should be interpreted with skepticism [ 50, 59].
A similar pattern (also surviving cluster correction) was apparent in the posterior cingulate cortex and adjacent left precuneus, potentially indicating a role of these regions as cross-hemispheric integrative nodes.
Preliminary studies on these distal sites show that some overlap with the enhancer mark H3K4me1 and/or H3K27ac (data not shown), potentially indicating a role for REST-directed repression at specified distal enhancer regions, an intriguing hypothesis that awaits future analysis.
Interestingly, UDP- C-GlcNAc did not show any inhibitory activity against hOGT (Hajduch et al. 2008), potentially indicating an essential role of the glycosidic oxygen atom in substrate binding.
A number of these properties are reflected in both the cell lines and patient material used within this study, potentially indicating a central role for cyclin D1 and Id1 in this subgroup.
ST6GAL1 loss is caused by aberrant ST6GAL1 promoter methylation potentially indicating a tumor suppressive role in bladder carcinogenesis.
Our study characterizes for the first time ST6GAL1 expression loss caused by aberrant ST6GAL1 promoter methylation potentially indicating a tumor suppressive role in bladder carcinogenesis.
Interestingly, protein modification was the biological process most strongly associated with regulatory subfunctionalization across all three species (Additional file 5: Figure S2), potentially indicating that such modifications play an important role in species differentiation.
