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The calyx of Held is a giant glutamatergic synapse in the mammalian auditory pathway designed to ensure faithful transmission of high frequency action potential trains.
ChEF and ChIEF allow more precise temporal control of depolarization, and can induce action potential trains that more closely resemble natural spiking patterns.
Our basic experiment comprised measuring GECI responses to high-frequency (83 Hz) action potential trains (Figure 2).
Loose-patch recordings revealed that somatic Ca2+ transients reliably reflected action potential trains and thus can be used as a reporter of UP state timings (Figure 6D).
With trains of four or more action potentials, GCaMP2 at room temperature allowed us to detect 100% of the action potential trains (Figure 5).
During action potential trains at 10 Hz, the normalized action potential amplitude (normalized to the first action potential) was 0.85±0.03 for ChAT+ neurons and 0.92±0.02 for ChAT− neurons (table 1; P = 0.0094, Mann-Whitney test).
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We're watching a potential train wreck".
What we have now is a potential train wreck.
Max Baucus, Democratic senator, referred to the implementation of your health-care as a potential train wreck.
Officials confirmed they were in talks with the US Ivy league Harvard University, whose business school has been identified as a potential training partner.
Immensely gifted but flawed, he is a jumble of self-regard, self-confidence and self-immolation — potential greatness and a potential train wreck in the same metrosexual package.
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