Although linkage analyses have met with some success (Houlihan et al. 2009; Dick et al. 2006; Luciano et al. 2006; Posthuma et al. 2005), these studies lack power to detect common variation and have difficulty pinpointing the variant of interest (Balding 2006).
Pinpointing the initial molecular trigger, however, is difficult.
Variations between the mutant and the mediator that recur in the WT are ignored, thus pinpointing the differences between the mutant and the WT.
GWAS allow researchers to pinpoint the genetic variations that are associated with susceptibility to complex disorders, such as bipolar disorder, coronary artery disease, Crohn's disease, hypertension, rheumatoid arthritis, and diabetes [ 1].
A comparative approach will be particularly important for pinpointing the regions responsible for pattern variation in Heliconius.
Thus, pinpointing the key alterations (driver mutations) from a background of variations with no direct causal link to cancer (passenger mutations) is difficult.
If genotypic variation in wild mammal populations underpinned key phenotypic variation in the innate immune response and this, in turn, determined susceptibility to parasitism, then pinpointing the loci involved would be of fundamental interest.
The variation involved means that accurately predicting which voices will be best for a particular job, independent of age, gender and ethnicity, means pinpointing the right combinations of vocal features.
The goal of this study was to quantify reproducibility within and between profiles generated using ChIP-chip and ChIP-seq approaches, and to pinpoint the source of variation between the technologies, which ultimately should provide useful information for experimental design and data analysis.
That should help researchers pinpoint the tiny genetic variations that correspond with valuable traits.
Armed with this specific information, the farmer can investigate selected areas and pinpoint the reasons for the variations (soil compaction or nutrient imbalance, for example), quantify them in financial terms, and find out if it is economical to implement remedies.
