The initial exclusion criteria were persons without peripheral blood hemoglobin (Hb) data (n = 23,279) and those with a past history of or who were being treated for hematologic disease or residents undergoing dialysis due to renal impairment (n = 107).
Monitoring included ECG, peripheral arterial hemoglobin oxygen saturation (Visconnet monitor, RGB Madrid, Spain), and the respiratory volumes and pressures, FiO2 and EtCO2, by means of a spirometer connected to the endotracheal tube and an S5 monitor (Datex Ohmeda, Madison, USA).
Transfer out of the ICU was considered in the presence of peripheral oxygen hemoglobin saturation (SpO2) ≥94% at an inspired fraction of oxygen (FiO2) ≤0.5 by facemask, adequate cardiac stability with no major arrhythmias, chest tube drainage <50 ml/h, urine output >0.5 ml/kg/h, no intravenous inotropic or vasopressor therapy in excess of dopamine 5 μg/kg/min, and no seizure activity.
peripheral saturation of hemoglobin with oxygen.
*Adjusted for age, sex, hypertension, dyslipidemia, smoking, previous stroke, previous myocardial infarction, peripheral vascular disease, hemoglobin and plasma creatinine concentrations.
It should be noted that ferritin and hemoglobin, peripheral biomarkers of body iron stores, are not the gold standard biomarkers of body iron.
At the onset of severe sepsis, the following parameters were recorded: age, sex, APACHE II, heart rate, mean arterial pressure, PaO2/FiO2, arterial pH, peripheral blood of hemoglobin, platelets and leukocyte concentration, and the number of organ failures.
Patients' characteristics at diagnosis including gender, age, immunophenotype, ISS stage, peripheral neuropathy (PN), hemoglobin, platelets, bone marrow (BM) plasma cell percentage, serum calcium, serum albumin, S β2M, serum lactate dehydrogenase (LDH), and serum creatinine were collected.
Statistical differences in the distribution of covariates, including sociodemographic characteristics, noise exposure, peripheral neuropathy, glycosylated hemoglobin, and vascular factors, were examined using a t test (for continuous characteristics) or χ test (for categorical characteristics).
AYAs in our study presented features of a more aggressive disease, with higher levels of WBC and blasts in the peripheral blood, lower hemoglobin, larger spleen size, and more frequent organomegaly-related symptoms.
