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These observations appear to confirm the hypothesis according to which mechanosensitivity of ORNs may be a peripheral drive to synchronize OB rhythmic activity with respiration [4].
This peripheral drive could contribute both to the transition to, and maintenance of, persistent muscle pain as seen in some "functional" pain syndromes.
Intra-articular anesthetic studies in hip and knee OA support a peripheral drive to pain in approximately 60% to 80% of patients, depending on the affected joint [ 3, 4].
There is strong evidence that, in most chronic pain conditions arising from nerve damage or inflammation, peripheral nerve block can cause pain relief in humans, proving that peripheral drive is critical to chronic pain (Aguirre et al., 2012).
It is, however, not known whether the increased brain activity observed at a lower threshold in the infants is due to increased peripheral drive, for example due to differences in skin thickness between the adult and infant populations, or due to differences in transduction or subsequent central processing of the nociceptive input.
We have highlighted the benefits of using a multi-dimensional approach to the assessment of infant pain; emphasised that these studies were conducted in newborn infants in the first seven days of life; and described the lack of certainty regarding whether observed differences between infant and adult activation patterns are due to differences in peripheral drive or subsequent central processing.
Similar(54)
Within this complex network, we identified an afferent MCC posterior insula pathway that can induce and maintain nociceptive hypersensitivity in the absence of conditioned peripheral noxious drive.
For oil reservoir with strong peripheral water drive or surrounded by peripheral injectors, Fig. 1 can represent the displace procedure well.
At least in elite apnea divers, the small increase in apnea time and similar PaO2 at breakpoint (∼31 mmHg) suggest the apnea breakpoint is more related to PaO2, rather than peripheral chemoreflex drive to breathe.
He admitted that so much is now digitally downloaded and guided me to a peripheral CD/DVD drive.
Under hyperoxia the ventilatory response to hypercapnia (HCVR) represents the central chemoreflex response only, assuming that the peripheral chemoreflex drive is suppressed by hyperoxia [ 16, 17].
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