Peripheral benzodiazepine receptors are ubiquitously expressed in various tissues, including the heart.
Peripheral benzodiazepine receptor (PBR) is associated with neuroinflammation and tumor progression.
Peripheral benzodiazepine receptors have been reported to be involved in the protection of cells against oxygen radical damage.
Peripheral benzodiazepine receptors (PBRs) are located on the outer membrane of mitochondria, and their density is increased in brain tumors.
Peripheral benzodiazepine receptors are present in peripheral nervous system tissues, glial cells, and to a lesser extent the central nervous system.
Peripheral benzodiazepine receptor-specific ligands have been shown to induce apoptosis and cell cycle arrest potently in human oesophageal cancer cells (Sutter et al, 2002).
Peripheral benzodiazepine receptor-specific ligands activate the p38MAPK signalling pathway, leading to overexpression of gadd45 and gadd153 and cell cycle arrest.
Peripheral benzodiazepine receptor-ligand-mediated apoptosis involves caspase-3 activation, leading to DNA fragmentation and cell death (Sutter et al, 2002).
Okubo, T., Yoshikawa, R., Chaki, S., Okuyama, S. & Nakazato, A. Design, synthesis, and structure activity relationships of novel tetracyclic compounds as peripheral benzodiazepine receptor ligands.
Translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), is an outer mitochondrial membrane protein.
However, recent studies showed that BZD also act on peripheral benzodiazepine receptor sites (PBR) or translocator protein 18 kDa (TSPO).
